MolNFT v1 · #117702 · protein

The cap binding site of influenza virus protein PB2 as a drug target

5EG7 · Polymerase basic protein 2: “The cap binding site of influenza virus protein PB2 as a drug target”. X-ray diffraction, 1 ligand (MGT), 1 pocket (best druggability 0.56). MolNFT v1 #117702 on GenesisL1: 3D structure, binding sites…

PDB: 5EG7
Type: protein
Length: 161 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Polymerase basic protein 2
UniProt: G3LZH2
Ligands: MGT
Pockets: 1 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 22% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Polymerase basic protein 2	protein	161	22% helix, 42% strand	G3LZH2

Ligands and binding sites

MGT · 7N-methyl-8-hydroguanosine-5'-triphosphate · ligand · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	152	0.56	0.81	21	MGT

Compared structures

5EG7 · The cap binding site of influenza virus protein PB2 as a drug target · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G3LZH2
Elsewhere: RCSB PDB 5EG7 · PDBe 5EG7 · UniProt G3LZH2

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