MolNFT v1 · #117583 · protein
Crystal structure of monobody MB(S4) bound to PRDM14 in complex with MTGR1
5ECJ · Pr domain zinc finger protein 14,PROTEIN CBFA2T2: “Crystal structure of monobody MB(S4) bound to PRDM14 in complex with MTGR1”. X-ray diffraction, 11 pockets (best druggability 0.65). MolNFT v1 #117583 on GenesisL1: 3D structure…
- PDB
- 5ECJ
- Type
- protein
- Length
- 712 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pr domain zinc finger protein 14,PROTEIN CBFA2T2; Monobody MB(S4)
- EC
- 2.1.1.-
- UniProt
- E9Q3T6, O70374
- Pockets
- 11 · best druggability 0.65
Structure
x-ray diffraction · 3 distinct chains · 26% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pr domain zinc finger protein 14,PROTEIN CBFA2T2 (EC 2.1.1.-) | protein | 263 | 30% helix, 26% strand | E9Q3T6, O70374 |
| F, E | Monobody MB(S4) | protein | 93 | 0% helix, 61% strand | — |
| B | Pr domain zinc finger protein 14,PROTEIN CBFA2T2 (EC 2.1.1.-) | protein | 263 | 31% helix, 27% strand | E9Q3T6, O70374 |
Pockets
11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 654 | 0.65 | 0.75 | 52 | empty |
| 2 | 78 | 0.63 | 0.90 | 22 | empty |
| 3 | 125 | 0.57 | 0.84 | 31 | empty |
| 4 | 315 | 0.57 | 0.76 | 36 | empty |
| 5 | 53 | 0.53 | 0.88 | 20 | empty |
Interfaces
3 interfaces between chains.
- A–B · 882 Ų buried · 9 hydrogen bonds · protein-protein
- A–E · 597 Ų buried · 7 hydrogen bonds · protein-protein
- F–B · 582 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 5ECJ · Crystal structure of monobody Mb(S4) bound to Prdm14 in complex with Mtgr1 · the same entry in another collection · chain E against E, TM-score 1.00
- E9Q3T6 · AlphaFold monomer V2.0 prediction for pr domain zinc finger protein 14 (E9Q3T6) · a predicted model of the same protein · chain A against A, TM-score 0.64
- O70374 · AlphaFold monomer V2.0 prediction for protein CBFA2T2 (O70374) · a predicted model of the same protein · chain A against A, TM-score 0.34
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E9Q3T6
- Every structure of UniProt O70374
- Elsewhere: RCSB PDB 5ECJ · PDBe 5ECJ · UniProt E9Q3T6 · UniProt O70374
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