MolNFT v1 · #117572 · protein
Crystal structure of a chimeric C-src-SH3 domain with the sequence of the rt-loop from the abl-SH3 domain at pH 5.0
5EC7 · Proto-oncogene tyrosine-protein kinase src: “Crystal structure of a chimeric C-src-SH3 domain with the sequence of the rt-loop from the abl-SH3 domain at…”. X-ray diffraction, 1 pocket (best druggability 0.34). MolNFT v1 #117572 on…
- PDB
- 5EC7
- Type
- protein
- Length
- 169 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proto-oncogene tyrosine-protein kinase src
- EC
- 2.7.10.2
- UniProt
- P00523
- Pockets
- 1 · best druggability 0.34
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Proto-oncogene tyrosine-protein kinase src (EC 2.7.10.2) | protein | 57 | 5% helix, 47% strand | P00523 |
| C | Proto-oncogene tyrosine-protein kinase src (EC 2.7.10.2) | protein | 55 | 5% helix, 45% strand | P00523 |
Ligands and binding sites
- PEG · Di(hydroxyethyl)ether · additive · 4 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 91 | 0.34 | 0.74 | 19 | empty |
Interfaces
3 interfaces between chains.
- A–C · 393 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 146 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 64 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5EC7 · Crystal structure of a chimeric c-Src-SH3 domain with the sequence of the RT-loop from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00523
- Elsewhere: RCSB PDB 5EC7 · PDBe 5EC7 · UniProt P00523
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