MolNFT v1 · #117474 · protein

Bovine Fab fragment F08_B11

5E99 · Fab F08_B11 light chain: “Bovine Fab fragment F08_B11”. X-ray diffraction, 4 pockets (best druggability 0.50). MolNFT v1 #117474 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5E99
Type: protein
Length: 486 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fab F08_B11 light chain; Fab F08_B11 heavy chain
Pockets: 4 · best druggability 0.50

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	Fab F08_B11 light chain	protein	213	7% helix, 52% strand	—
H	Fab F08_B11 heavy chain	protein	273	5% helix, 49% strand	—

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	317	0.50	0.73	36	empty
2	102	0.39	0.76	24	empty
3	54	0.37	0.80	18	empty
4	54	0.26	0.73	13	empty

Interfaces

1 interface between chains.

L–H · 2163 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 10 disulfide (disulfide).

Compared structures

5E99 · Bovine Fab fragment F08_B11 · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5E99 · PDBe 5E99

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