MolNFT v1 · #117424 · protein
Hexameric structure of a lona protease domain in active state
5E7S · Lon protease: “Hexameric structure of a lona protease domain in active state”. X-ray diffraction, 20 pockets (best druggability 0.75). MolNFT v1 #117424 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5E7S
- Type
- protein
- Length
- 3,443 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lon protease
- EC
- 3.4.21.53
- UniProt
- A0A059VAZ3
- Pockets
- 20 · best druggability 0.75
Structure
x-ray diffraction · 6 distinct chains · 44% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, K | Lon protease (EC 3.4.21.53) | protein | 288 | 42% helix, 20% strand | A0A059VAZ3 |
| C, F, H, I | Lon protease (EC 3.4.21.53) | protein | 287 | 43% helix, 20% strand | A0A059VAZ3 |
| D, J | Lon protease (EC 3.4.21.53) | protein | 289 | 43% helix, 21% strand | A0A059VAZ3 |
| E | Lon protease (EC 3.4.21.53) | protein | 288 | 47% helix, 21% strand | A0A059VAZ3 |
| G | Lon protease (EC 3.4.21.53) | protein | 289 | 44% helix, 19% strand | A0A059VAZ3 |
| L | Lon protease (EC 3.4.21.53) | protein | 276 | 43% helix, 21% strand | A0A059VAZ3 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1078 | 0.75 | 0.78 | 135 | empty |
| 2 | 821 | 0.74 | 0.79 | 68 | empty |
| 3 | 665 | 0.69 | 0.77 | 89 | empty |
| 4 | 496 | 0.66 | 0.78 | 57 | empty |
| 5 | 395 | 0.66 | 0.79 | 40 | empty |
Interfaces
18 interfaces between chains.
- I–J · 842 Ų buried · 13 hydrogen bonds · protein-protein
- H–I · 804 Ų buried · 13 hydrogen bonds · protein-protein
- K–L · 796 Ų buried · 13 hydrogen bonds · protein-protein
- A–F · 794 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 786 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 5E7S · Hexameric structure of a LonA protease domain in active state · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A059VAZ3
- Elsewhere: RCSB PDB 5E7S · PDBe 5E7S · UniProt A0A059VAZ3
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