MolNFT v1 · #11740 · protein
Kcsa potassium channel with tba (tetrabutylammonium) and rubidium
1JVM · Voltage-gated potassium channel: “Kcsa potassium channel with tba (tetrabutylammonium) and rubidium”. X-ray diffraction, 2 ligands (TBA, RB), 4 pockets (best druggability 0.82). MolNFT v1 #11740 on GenesisL1: 3D structure, binding…
- PDB
- 1JVM
- Type
- protein
- Length
- 394 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Voltage-gated potassium channel
- UniProt
- P0A334
- Ligands
- TBA, RB
- Pockets
- 4 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 66% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Voltage-gated potassium channel | protein | 97 | 67% helix, 0% strand | P0A334 |
| B, D | Voltage-gated potassium channel | protein | 100 | 65% helix, 0% strand | P0A334 |
Ligands and binding sites
- TBA · Tetrabutylammonium ion · ligand · chains A, B, D
- RB · Rubidium ion · metal · 3 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 627 | 0.82 | 0.87 | 64 | TBA |
| 2 | 63 | 0.68 | 0.95 | 20 | empty |
| 3 | 129 | 0.44 | 0.76 | 30 | empty |
| 4 | 133 | 0.42 | 0.75 | 25 | empty |
Interfaces
6 interfaces between chains.
- A–D · 911 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 904 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 901 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 891 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 29 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1JVM · Kcsa potassium channel with tba (tetrabutylammonium) and rubidium · the same entry in another collection · chain A against A, TM-score 1.00
- P0A334 · AlphaFold monomer V2.0 prediction for pH-gated potassium channel kcsa (P0A334) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A334
- Elsewhere: RCSB PDB 1JVM · PDBe 1JVM · UniProt P0A334
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.