MolNFT v1 · #117151 · protein
Human T-cell immunoglobulin and mucin domain protein 4
5DZN · T-cell immunoglobulin and mucin domain-containing protein 4: “Human T-cell immunoglobulin and mucin domain protein 4”. X-ray diffraction, 16 pockets (best druggability 0.55). MolNFT v1 #117151 on GenesisL1: 3D structure, binding…
- PDB
- 5DZN
- Type
- protein
- Length
- 911 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- T-cell immunoglobulin and mucin domain-containing protein 4
- UniProt
- Q96H15
- Pockets
- 16 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, H | T-cell immunoglobulin and mucin domain-containing protein 4 | protein | 114 | 5% helix, 42% strand | Q96H15 |
| G | T-cell immunoglobulin and mucin domain-containing protein 4 | protein | 113 | 5% helix, 42% strand | Q96H15 |
Pockets
16 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 258 | 0.55 | 0.77 | 27 | empty |
| 2 | 301 | 0.53 | 0.75 | 27 | empty |
| 3 | 249 | 0.53 | 0.76 | 32 | empty |
| 4 | 275 | 0.52 | 0.75 | 30 | empty |
| 5 | 196 | 0.48 | 0.76 | 28 | empty |
Interfaces
16 interfaces between chains.
- B–F · 586 Ų buried · 19 hydrogen bonds · protein-protein
- D–G · 558 Ų buried · 21 hydrogen bonds · protein-protein
- C–H · 553 Ų buried · 20 hydrogen bonds · protein-protein
- A–E · 546 Ų buried · 21 hydrogen bonds · protein-protein
- C–F · 209 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 24 disulfide (disulfide).
Compared structures
- 5DZN · human T-cell immunoglobulin and mucin domain protein 4 · the same entry in another collection · chain H against H, TM-score 1.00
- Q96H15 · AlphaFold monomer V2.0 prediction for T-cell immunoglobulin and mucin domain-containing… · a predicted model of the same protein · chain G against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96H15
- Elsewhere: RCSB PDB 5DZN · PDBe 5DZN · UniProt Q96H15
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