MolNFT v1 · #117150 · protein
HIV-1 reverse transcriptase rh domain
5DZM · Ribonuclease H: “HIV-1 reverse transcriptase rh domain”. X-ray diffraction, 1 pocket (best druggability 0.76). MolNFT v1 #117150 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5DZM
- Type
- protein
- Length
- 454 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribonuclease H
- EC
- 3.1.26.4
- UniProt
- Q7LYY8
- Pockets
- 1 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Ribonuclease H (EC 3.1.26.4) | protein | 115 | 35% helix, 30% strand | Q7LYY8 |
| D, B | Ribonuclease H (EC 3.1.26.4) | protein | 112 | 34% helix, 31% strand | Q7LYY8 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1105 | 0.76 | 0.79 | 79 | empty |
Interfaces
6 interfaces between chains.
- D–C · 2812 Ų buried · 35 hydrogen bonds · protein-protein
- A–B · 2810 Ų buried · 36 hydrogen bonds · protein-protein
- D–B · 738 Ų buried · 4 hydrogen bonds · protein-protein
- C–B · 582 Ų buried · 6 hydrogen bonds · protein-protein
- A–D · 579 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 5DZM · HIV-1 Reverse Transcriptase RH domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7LYY8
- Elsewhere: RCSB PDB 5DZM · PDBe 5DZM · UniProt Q7LYY8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.