MolNFT v1 · #11710 · protein

Crystal structure of calcium-free human sorcin: a member of the penta-ef-hand protein family

1JUO: “Crystal structure of calcium-free human sorcin: a member of the penta-ef-hand protein family”. X-ray diffraction, 4 pockets (best druggability 0.57). MolNFT v1 #11710 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1JUO
Type: protein
Length: 344 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sorcin
UniProt: P30626
Pockets: 4 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 56% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Sorcin	protein	172	56% helix, 8% strand	P30626

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	282	0.57	0.77	40	empty
2	76	0.51	0.84	21	empty
3	155	0.48	0.78	21	empty
4	93	0.38	0.76	12	empty

Interfaces

1 interface between chains.

A–B · 1818 Å² buried · 26 hydrogen bonds · protein-protein

Compared structures

1JUO · Crystal Structure of Calcium-free Human Sorcin: A Member of the Penta-EF-Hand Protein… · the same entry in another collection · chain A against A, TM-score 1.00
P30626 · AlphaFold monomer V2.0 prediction for sorcin (P30626) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P30626
Elsewhere: RCSB PDB 1JUO · PDBe 1JUO · UniProt P30626

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