MolNFT v1 · #117058 · protein
Crystal structure of a substrate-free glutamate transporter homologue glttk
5DWY · PROTON/GLUTAMATE symporter, sdf family: “Crystal structure of a substrate-free glutamate transporter homologue glttk”. X-ray diffraction, 20 pockets (best druggability 0.88). MolNFT v1 #117058 on GenesisL1: 3D structure, binding…
- PDB
- 5DWY
- Type
- protein
- Length
- 1,281 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- PROTON/GLUTAMATE symporter, sdf family
- UniProt
- Q5JID0
- Pockets
- 20 · best druggability 0.88
Structure
x-ray diffraction · 3 distinct chains · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | PROTON/GLUTAMATE symporter, sdf family | protein | 426 | 78% helix, 0% strand | Q5JID0 |
| B | PROTON/GLUTAMATE symporter, sdf family | protein | 428 | 78% helix, 0% strand | Q5JID0 |
| C | PROTON/GLUTAMATE symporter, sdf family | protein | 427 | 78% helix, 0% strand | Q5JID0 |
Ligands and binding sites
- PEG · Di(hydroxyethyl)ether · additive · 23 copies · chains A, B, C
- PGE · Triethylene glycol · additive · 11 copies · chains A, B, C
- BOG · octyl beta-D-glucopyranoside · additive · 2 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 542 | 0.88 | 0.93 | 46 | empty |
| 2 | 64 | 0.66 | 0.93 | 17 | empty |
| 3 | 559 | 0.63 | 0.74 | 72 | PEG, PGE |
| 4 | 198 | 0.62 | 0.82 | 29 | empty |
| 5 | 536 | 0.62 | 0.74 | 71 | PGE |
Interfaces
3 interfaces between chains.
- B–C · 1192 Ų buried · 14 hydrogen bonds · protein-protein
- A–C · 1186 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 1155 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 5DWY · Crystal structure of a substrate-free glutamate transporter homologue GltTk · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5JID0
- Elsewhere: RCSB PDB 5DWY · PDBe 5DWY · UniProt Q5JID0
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.