MolNFT v1 · #117009 · protein
Crystal structure of S. cerevisiae TSA2
5DVB · TSA2P: “Crystal structure of S. cerevisiae TSA2”. X-ray diffraction, 20 pockets (best druggability 0.73). MolNFT v1 #117009 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5DVB
- Type
- protein
- Length
- 1,776 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TSA2P
- UniProt
- A0A0D4RBH7
- Pockets
- 20 · best druggability 0.73
Structure
x-ray diffraction · 8 distinct chains · 30% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H, G | TSA2P | protein | 171 | 30% helix, 27% strand | A0A0D4RBH7 |
| B | TSA2P | protein | 176 | 31% helix, 26% strand | A0A0D4RBH7 |
| C, J | TSA2P | protein | 172 | 31% helix, 27% strand | A0A0D4RBH7 |
| A | TSA2P | protein | 199 | 30% helix, 25% strand | A0A0D4RBH7 |
| I | TSA2P | protein | 186 | 29% helix, 25% strand | A0A0D4RBH7 |
| D | TSA2P | protein | 170 | 30% helix, 28% strand | A0A0D4RBH7 |
| E | TSA2P | protein | 183 | 27% helix, 26% strand | A0A0D4RBH7 |
| F | TSA2P | protein | 176 | 29% helix, 27% strand | A0A0D4RBH7 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 62 | 0.73 | 0.99 | 24 | empty |
| 2 | 61 | 0.73 | 0.99 | 24 | empty |
| 3 | 65 | 0.73 | 0.98 | 23 | empty |
| 4 | 59 | 0.72 | 0.98 | 24 | empty |
| 5 | 62 | 0.72 | 0.98 | 22 | empty |
Interfaces
12 interfaces between chains.
- B–A · 1679 Ų buried · 25 hydrogen bonds · protein-protein
- E–F · 1182 Ų buried · 20 hydrogen bonds · protein-protein
- I–J · 1161 Ų buried · 19 hydrogen bonds · protein-protein
- C–D · 1038 Ų buried · 20 hydrogen bonds · protein-protein
- H–G · 1024 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 5DVB · Crystal Structure of S. cerevisiae TSA2 · the same entry in another collection · chain I against I, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0D4RBH7
- Elsewhere: RCSB PDB 5DVB · PDBe 5DVB · UniProt A0A0D4RBH7
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