MolNFT v1 · #116928 · protein
Crystal structure of human proteasome ALPHA7 tetradecamer
5DSV · Proteasome subunit alpha type-3: “Crystal structure of human proteasome ALPHA7 tetradecamer”. X-ray diffraction, 20 pockets (best druggability 0.71). MolNFT v1 #116928 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5DSV
- Type
- protein
- Length
- 3,392 residues
- Chains
- 14
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proteasome subunit alpha type-3
- EC
- 3.4.25.1
- UniProt
- P25788
- Pockets
- 20 · best druggability 0.71
Structure
x-ray diffraction · 8 distinct chains · 38% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D, F, N | Proteasome subunit alpha type-3 (EC 3.4.25.1) | protein | 244 | 36% helix, 23% strand | P25788 |
| B, E, L | Proteasome subunit alpha type-3 (EC 3.4.25.1) | protein | 245 | 38% helix, 22% strand | P25788 |
| C | Proteasome subunit alpha type-3 (EC 3.4.25.1) | protein | 234 | 38% helix, 22% strand | P25788 |
| G | Proteasome subunit alpha type-3 (EC 3.4.25.1) | protein | 242 | 37% helix, 23% strand | P25788 |
| H | Proteasome subunit alpha type-3 (EC 3.4.25.1) | protein | 239 | 38% helix, 23% strand | P25788 |
| I, K | Proteasome subunit alpha type-3 (EC 3.4.25.1) | protein | 244 | 38% helix, 23% strand | P25788 |
| J | Proteasome subunit alpha type-3 (EC 3.4.25.1) | protein | 239 | 38% helix, 23% strand | P25788 |
| M | Proteasome subunit alpha type-3 (EC 3.4.25.1) | protein | 239 | 38% helix, 23% strand | P25788 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 494 | 0.71 | 0.81 | 70 | empty |
| 2 | 703 | 0.71 | 0.78 | 75 | empty |
| 3 | 512 | 0.71 | 0.80 | 64 | empty |
| 4 | 741 | 0.71 | 0.77 | 76 | empty |
| 5 | 655 | 0.70 | 0.78 | 68 | empty |
Interfaces
28 interfaces between chains.
- J–K · 1357 Ų buried · 15 hydrogen bonds · protein-protein
- K–L · 1350 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 1342 Ų buried · 13 hydrogen bonds · protein-protein
- H–N · 1338 Ų buried · 14 hydrogen bonds · protein-protein
- D–E · 1338 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 13 disulfide (disulfide).
Compared structures
- 5DSV · Crystal structure of human proteasome alpha7 tetradecamer · the same entry in another collection · chain N against N, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P25788
- Elsewhere: RCSB PDB 5DSV · PDBe 5DSV · UniProt P25788
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