MolNFT v1 · #11681 · protein

Crystal structure of 17BETA-hydroxysteroid dehydrogenase type 1 complexed with testosterone

1JTV · 17 beta-hydroxysteroid dehydrogenase type 1: “Crystal structure of 17BETA-hydroxysteroid dehydrogenase type 1 complexed with testosterone”. X-ray diffraction, 1 ligand (TES), 1 pocket (best druggability 0.71). MolNFT v1 #11681 on…

PDB: 1JTV
Type: protein
Length: 278 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 17 beta-hydroxysteroid dehydrogenase type 1
EC: 1.1.1.62
UniProt: P14061
Ligands: TES
Pockets: 1 · best druggability 0.71

Structure

x-ray diffraction · 1 distinct chain · 55% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	17 beta-hydroxysteroid dehydrogenase type 1 (EC 1.1.1.62)	protein	278	55% helix, 15% strand	P14061

Ligands and binding sites

TES · Testosterone · ligand · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	610	0.71	0.79	55	TES

Compared structures

1JTV · Crystal structure of 17beta-Hydroxysteroid Dehydrogenase Type 1 complexed with… · the same entry in another collection · chain A against A, TM-score 1.00
P14061 · AlphaFold monomer V2.0 prediction for 17-beta-hydroxysteroid dehydrogenase type 1 (P14061) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P14061
Elsewhere: RCSB PDB 1JTV · PDBe 1JTV · UniProt P14061

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.