MolNFT v1 · #11668 · protein
Crystal structure and biophysical properties of a complex between the N-terminal region of SNAP25 and the snare region of syntaxin 1A
1JTH: “Crystal structure and biophysical properties of a complex between the N-terminal region of SNAP25 and the…”. X-ray diffraction, 1 pocket (best druggability 0.38). MolNFT v1 #11668 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1JTH
- Type
- protein
- Length
- 249 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SNAP25; Syntaxin 1A
- UniProt
- P60881, P32851
- Pockets
- 1 · best druggability 0.38
Structure
x-ray diffraction · 4 distinct chains · 97% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SNAP25 | protein | 62 | 97% helix, 0% strand | P60881 |
| B | Syntaxin 1A | protein | 67 | 97% helix, 0% strand | P32851 |
| C | SNAP25 | protein | 69 | 97% helix, 0% strand | P60881 |
| D | Syntaxin 1A | protein | 51 | 96% helix, 0% strand | P32851 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 82 | 0.38 | 0.77 | 17 | empty |
Interfaces
6 interfaces between chains.
- B–C · 1498 Ų buried · 10 hydrogen bonds · protein-protein
- A–D · 1334 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 1267 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 1241 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 392 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1JTH · Crystal structure and biophysical properties of a complex between the N-terminal region… · the same entry in another collection · chain D against D, TM-score 1.00
- P60881 · AlphaFold monomer V2.0 prediction for synaptosomal-associated protein 25 (P60881) · a predicted model of the same protein · chain A against A, TM-score 0.91
- P32851 · AlphaFold monomer V2.0 prediction for syntaxin-1A (P32851) · a predicted model of the same protein · chain D against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P60881
- Every structure of UniProt P32851
- Elsewhere: RCSB PDB 1JTH · PDBe 1JTH · UniProt P60881 · UniProt P32851
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