MolNFT v1 · #116322 · protein
A dimerization-dependent mechanism drives prrsv NSP11 functions as a beta interferon antagonist and endoribonuclease
5DA1: “A dimerization-dependent mechanism drives prrsv NSP11 functions as a beta interferon antagonist and…”. X-ray diffraction, 2 pockets (best druggability 0.47). MolNFT v1 #116322 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5DA1
- Type
- protein
- Length
- 427 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Endoribonuclease
- UniProt
- E3V2B6
- Pockets
- 2 · best druggability 0.47
Structure
x-ray diffraction · 2 distinct chains · 16% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Endoribonuclease | protein | 222 | 16% helix, 37% strand | E3V2B6 |
| B | Endoribonuclease | protein | 205 | 16% helix, 31% strand | E3V2B6 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 57 | 0.47 | 0.84 | 15 | empty |
| 2 | 69 | 0.30 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 657 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 5DA1 · A Dimerization-Dependent Mechanism Drives PRRSV NSP11 Functions As a Beta Interferon… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E3V2B6
- Elsewhere: RCSB PDB 5DA1 · PDBe 5DA1 · UniProt E3V2B6
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