MolNFT v1 · #116106 · protein
Crystal structure of full length human glutaminase C expressed in E.COLI
5D3O · Glutaminase kidney isoform, mitochondrial: “Crystal structure of full length human glutaminase C expressed in E.COLI”. X-ray diffraction, 8 pockets (best druggability 0.72). MolNFT v1 #116106 on GenesisL1: 3D structure, binding…
- PDB
- 5D3O
- Type
- protein
- Length
- 780 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutaminase kidney isoform, mitochondrial
- EC
- 3.5.1.2
- UniProt
- O94925
- Pockets
- 8 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutaminase kidney isoform, mitochondrial (EC 3.5.1.2) | protein | 391 | 48% helix, 13% strand | O94925 |
| B | Glutaminase kidney isoform, mitochondrial (EC 3.5.1.2) | protein | 389 | 49% helix, 11% strand | O94925 |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 691 | 0.72 | 0.79 | 84 | empty |
| 2 | 361 | 0.68 | 0.82 | 42 | empty |
| 3 | 180 | 0.60 | 0.82 | 23 | empty |
| 4 | 196 | 0.48 | 0.75 | 33 | empty |
| 5 | 89 | 0.37 | 0.76 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1619 Ų buried · 26 hydrogen bonds · protein-protein
Compared structures
- 5D3O · Crystal structure of full length human glutaminase C expressed in E.coli · the same entry in another collection · chain A against A, TM-score 1.00
- O94925 · AlphaFold monomer V2.0 prediction for glutaminase kidney isoform, mitochondrial (O94925) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O94925
- Elsewhere: RCSB PDB 5D3O · PDBe 5D3O · UniProt O94925
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