MolNFT v1 · #115938 · protein

X-ray structure of human rbpms

5CYJ · RNA-binding protein with multiple splicing: “X-ray structure of human rbpms”. X-ray diffraction, 2 pockets (best druggability 0.68). MolNFT v1 #115938 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5CYJ
Type: protein
Length: 182 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-binding protein with multiple splicing
UniProt: Q93062
Pockets: 2 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 24% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	RNA-binding protein with multiple splicing	protein	91	24% helix, 26% strand	Q93062

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	433	0.68	0.79	31	empty
2	68	0.33	0.75	19	empty

Interfaces

1 interface between chains.

A–B · 633 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 modified (engineered).

Compared structures

5CYJ · X-ray structure of human RBPMS · the same entry in another collection · chain A against A, TM-score 1.00
Q93062 · AlphaFold monomer V2.0 prediction for RNA-binding protein with multiple splicing (Q93062) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q93062
Elsewhere: RCSB PDB 5CYJ · PDBe 5CYJ · UniProt Q93062

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