MolNFT v1 · #115935 · protein
Crystal structure of isoform 2 of uridine phosphorylase from schistosoma mansoni apo form
5CYG · Putative uridine phosphorylase: “Crystal structure of isoform 2 of uridine phosphorylase from schistosoma mansoni apo form”. X-ray diffraction, 5 pockets (best druggability 0.80). MolNFT v1 #115935 on GenesisL1: 3D structure…
- PDB
- 5CYG
- Type
- protein
- Length
- 565 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative uridine phosphorylase
- EC
- 2.4.2.3
- UniProt
- G4VGH9
- Pockets
- 5 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative uridine phosphorylase (EC 2.4.2.3) | protein | 285 | 34% helix, 25% strand | G4VGH9 |
| B | Putative uridine phosphorylase (EC 2.4.2.3) | protein | 280 | 36% helix, 26% strand | G4VGH9 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1189 | 0.80 | 0.82 | 122 | empty |
| 2 | 308 | 0.73 | 0.86 | 44 | empty |
| 3 | 67 | 0.50 | 0.85 | 18 | empty |
| 4 | 59 | 0.45 | 0.84 | 16 | empty |
| 5 | 85 | 0.36 | 0.76 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 2490 Ų buried · 29 hydrogen bonds · protein-protein
Compared structures
- 5CYG · Crystal Structure of isoform 2 of uridine phosphorylase from Schistosoma mansoni APO form · the same entry in another collection · chain A against A, TM-score 1.00
- G4VGH9 · AlphaFold monomer V2.0 prediction for inactive uridine phosphorylase B (G4VGH9) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G4VGH9
- Elsewhere: RCSB PDB 5CYG · PDBe 5CYG · UniProt G4VGH9
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