MolNFT v1 · #115913 · protein
Crystal structure of isoform 2 of purine nucleoside phosphorylase from schistosoma mansoni in apo form
5CXQ: “Crystal structure of isoform 2 of purine nucleoside phosphorylase from schistosoma mansoni in apo form”. X-ray diffraction, 3 pockets (best druggability 0.63). MolNFT v1 #115913 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 5CXQ
- Type
- protein
- Length
- 284 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Purine nucleoside phosphorylase
- EC
- 2.4.2.1
- UniProt
- G4VP83
- Pockets
- 3 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Purine nucleoside phosphorylase (EC 2.4.2.1) | protein | 284 | 38% helix, 24% strand | G4VP83 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 146 | 0.63 | 0.85 | 25 | empty |
| 2 | 153 | 0.47 | 0.77 | 24 | empty |
| 3 | 53 | 0.36 | 0.79 | 14 | empty |
Compared structures
- 5CXQ · Crystal Structure of Isoform 2 of Purine Nucleoside Phosphorylase from Schistosoma… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G4VP83
- Elsewhere: RCSB PDB 5CXQ · PDBe 5CXQ · UniProt G4VP83
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