MolNFT v1 · #115885 · protein
Crystal structure of chaetomium thermophilum NUP192 tail domain
5CWV · Nucleoporin NUP192: “Crystal structure of chaetomium thermophilum NUP192 tail domain”. X-ray diffraction, 3 pockets (best druggability 0.72). MolNFT v1 #115885 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5CWV
- Type
- protein
- Length
- 538 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoporin NUP192
- UniProt
- G0S4T0
- Pockets
- 3 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleoporin NUP192 | protein | 273 | 73% helix, 0% strand | G0S4T0 |
| B | Nucleoporin NUP192 | protein | 265 | 74% helix, 0% strand | G0S4T0 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 71 | 0.72 | 0.97 | 22 | empty |
| 2 | 445 | 0.62 | 0.77 | 43 | empty |
| 3 | 70 | 0.29 | 0.73 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 680 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0S4T0
- Elsewhere: RCSB PDB 5CWV · PDBe 5CWV · UniProt G0S4T0
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