MolNFT v1 · #115883 · protein

Crystal structure of chaetomium thermophilum NUP57

5CWT · Nucleoporin NUP57: “Crystal structure of chaetomium thermophilum NUP57”. X-ray diffraction, 2 pockets (best druggability 0.34). MolNFT v1 #115883 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5CWT
Type: protein
Length: 152 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nucleoporin NUP57
UniProt: G0S0R2
Pockets: 2 · best druggability 0.34

Structure

x-ray diffraction · 4 distinct chains · 92% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nucleoporin NUP57	protein	41	90% helix, 0% strand	G0S0R2
B	Nucleoporin NUP57	protein	36	92% helix, 0% strand	G0S0R2
C	Nucleoporin NUP57	protein	40	95% helix, 0% strand	G0S0R2
D	Nucleoporin NUP57	protein	35	91% helix, 0% strand	G0S0R2

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	81	0.34	0.74	16	empty
2	87	0.33	0.74	15	empty

Interfaces

6 interfaces between chains.

A–B · 873 Å² buried · 3 hydrogen bonds · protein-protein
C–D · 872 Å² buried · 4 hydrogen bonds · protein-protein
A–C · 674 Å² buried · 0 hydrogen bonds · protein-protein
B–D · 512 Å² buried · 11 hydrogen bonds · protein-protein
A–D · 279 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

5CWT · Crystal structure of Chaetomium thermophilum Nup57 · the same entry in another collection · chain D against D, TM-score 1.00
G0S0R2 · AlphaFold monomer V2.0 prediction for nucleoporin NUP57 (G0S0R2) · a predicted model of the same protein · chain C against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G0S0R2
Elsewhere: RCSB PDB 5CWT · PDBe 5CWT · UniProt G0S0R2

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