MolNFT v1 · #115871 · protein
Crystal structure of de novo designed helical repeat protein DHR14
5CWH: “Crystal structure of de novo designed helical repeat protein DHR14”. X-ray diffraction, 4 pockets (best druggability 0.31). MolNFT v1 #115871 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5CWH
- Type
- protein
- Length
- 159 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Designed helical repeat protein
- Pockets
- 4 · best druggability 0.31
Structure
x-ray diffraction · 1 distinct chain · 85% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Designed helical repeat protein | protein | 159 | 85% helix, 0% strand | — |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 57 | 0.31 | 0.76 | 15 | empty |
| 2 | 56 | 0.31 | 0.76 | 15 | empty |
| 3 | 50 | 0.31 | 0.77 | 15 | empty |
| 4 | 56 | 0.30 | 0.76 | 16 | EDO |
Compared structures
- 5CWH · Crystal structure of de novo designed helical repeat protein DHR14 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5CWH · PDBe 5CWH
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