MolNFT v1 · #11586 · protein

Structure of uroporphyrinogen III synthase

1JR2 · Uroporphyrinogen-III synthase: “Structure of uroporphyrinogen III synthase”. X-ray diffraction, 4 pockets (best druggability 0.53). MolNFT v1 #11586 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1JR2
Type: protein
Length: 520 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uroporphyrinogen-III synthase
EC: 4.2.1.75
UniProt: P10746
Pockets: 4 · best druggability 0.53

Structure

x-ray diffraction · 1 distinct chain · 48% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Uroporphyrinogen-III synthase (EC 4.2.1.75)	protein	260	48% helix, 20% strand	P10746

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	300	0.53	0.74	31	empty
2	115	0.36	0.73	17	empty
3	54	0.29	0.75	15	empty
4	67	0.28	0.73	17	empty

Interfaces

1 interface between chains.

A–B · 539 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

1JR2 · Structure of Uroporphyrinogen III Synthase · the same entry in another collection · chain A against A, TM-score 1.00
P10746 · AlphaFold monomer V2.0 prediction for uroporphyrinogen-III synthase (P10746) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10746
Elsewhere: RCSB PDB 1JR2 · PDBe 1JR2 · UniProt P10746

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