MolNFT v1 · #115840 · protein

WDR48 (uaf-1), residues 2-580

5CVL · Wd repeat-containing protein 48: “WDR48 (uaf-1), residues 2-580”. X-ray diffraction, 2 ligands (AU, PO4), 4 pockets (best druggability 0.79). MolNFT v1 #115840 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5CVL
Type: protein
Length: 526 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Wd repeat-containing protein 48
UniProt: Q8TAF3
Ligands: AU, PO4
Pockets: 4 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 10% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Wd repeat-containing protein 48	protein	526	10% helix, 41% strand	Q8TAF3

Ligands and binding sites

AU · Gold ion · metal · 7 copies · chains A
PO4 · Phosphate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	723	0.79	0.83	57	empty
2	160	0.55	0.81	24	empty
3	147	0.42	0.75	32	AU
4	81	0.36	0.76	21	empty

Compared structures

5CVL · WDR48 (UAF-1), residues 2-580 · the same entry in another collection · chain A against A, TM-score 1.00
Q8TAF3 · AlphaFold monomer V2.0 prediction for wd repeat-containing protein 48 (Q8TAF3) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8TAF3
Elsewhere: RCSB PDB 5CVL · PDBe 5CVL · UniProt Q8TAF3

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