MolNFT v1 · #115777 · protein
Crystal structure of human SART3 hat-C domain-human USP4 dusp-ubl domain complex
5CTR · Squamous cell carcinoma antigen recognized by T-cells 3: “Crystal structure of human SART3 hat-C domain-human USP4 dusp-ubl domain complex”. X-ray diffraction, 12 pockets (best druggability 0.76). MolNFT v1 #115777 on GenesisL1: 3D…
- PDB
- 5CTR
- Type
- protein
- Length
- 1,031 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Squamous cell carcinoma antigen recognized by T-cells 3; Ubiquitin carboxyl-terminal…
- EC
- 3.4.19.12
- UniProt
- Q15020, Q13107
- Pockets
- 12 · best druggability 0.76
Structure
x-ray diffraction · 4 distinct chains · 56% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Squamous cell carcinoma antigen recognized by T-cells 3 | protein | 308 | 80% helix, 0% strand | Q15020 |
| B | Squamous cell carcinoma antigen recognized by T-cells 3 | protein | 305 | 78% helix, 0% strand | Q15020 |
| C | Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) | protein | 206 | 22% helix, 22% strand | Q13107 |
| D | Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) | protein | 212 | 22% helix, 27% strand | Q13107 |
Pockets
12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 709 | 0.76 | 0.81 | 51 | empty |
| 2 | 705 | 0.74 | 0.80 | 70 | empty |
| 3 | 1141 | 0.74 | 0.77 | 79 | empty |
| 4 | 255 | 0.60 | 0.80 | 32 | empty |
| 5 | 234 | 0.58 | 0.79 | 31 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1455 Ų buried · 33 hydrogen bonds · protein-protein
- A–C · 752 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 699 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 5CTR · Crystal structure of human SART3 HAT-C domain-human USP4 DUSP-UBL domain complex · the same entry in another collection · chain D against D, TM-score 1.00
- Q15020 · AlphaFold monomer V2.0 prediction for squamous cell carcinoma antigen recognized by… · a predicted model of the same protein · chain B against A, TM-score 0.98
- Q13107 · AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase 4 (Q13107) · a predicted model of the same protein · chain D against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15020
- Every structure of UniProt Q13107
- Elsewhere: RCSB PDB 5CTR · PDBe 5CTR · UniProt Q15020 · UniProt Q13107
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