MolNFT v1 · #115739 · protein

Yeast chorismate mutase, T226S mutant, complex with TRP

5CSM: “Yeast chorismate mutase, T226S mutant, complex with TRP”. X-ray diffraction, 1 ligand (TRP), 2 pockets (best druggability 0.69). MolNFT v1 #115739 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5CSM
Type: protein
Length: 250 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chorismate mutase
EC: 5.4.99.5
UniProt: P32178
Ligands: TRP
Pockets: 2 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 62% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Chorismate mutase (EC 5.4.99.5)	protein	250	62% helix, 0% strand	P32178

Ligands and binding sites

TRP · Tryptophan · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	313	0.69	0.83	25	empty
2	134	0.45	0.77	20	empty

Compared structures

5CSM · Yeast chorismate mutase, T226S mutant, complex with TRP · the same entry in another collection · chain A against A, TM-score 1.00
P32178 · AlphaFold monomer V2.0 prediction for chorismate mutase (P32178) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P32178
Elsewhere: RCSB PDB 5CSM · PDBe 5CSM · UniProt P32178

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