MolNFT v1 · #115710 · protein
Refined structure of cro repressor protein from bacteriophage lambda
5CRO: “Refined structure of cro repressor protein from bacteriophage lambda”. X-ray diffraction, 1 ligand (PO4), 5 pockets (best druggability 0.56). MolNFT v1 #115710 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5CRO
- Type
- protein
- Length
- 243 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cro repressor protein
- UniProt
- P03040
- Ligands
- PO4
- Pockets
- 5 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| O | Cro repressor protein | protein | 60 | 43% helix, 30% strand | P03040 |
| A, B, C | Cro repressor protein | protein | 61 | 43% helix, 30% strand | P03040 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 2 copies · chains O
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 118 | 0.56 | 0.83 | 19 | empty |
| 2 | 89 | 0.51 | 0.83 | 15 | empty |
| 3 | 84 | 0.34 | 0.75 | 20 | empty |
| 4 | 68 | 0.33 | 0.75 | 16 | empty |
| 5 | 68 | 0.30 | 0.73 | 20 | empty |
Interfaces
6 interfaces between chains.
- A–C · 677 Ų buried · 10 hydrogen bonds · protein-protein
- O–B · 666 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 573 Ų buried · 8 hydrogen bonds · protein-protein
- O–C · 525 Ų buried · 11 hydrogen bonds · protein-protein
- O–A · 275 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 5CRO · Refined structure of cro repressor protein from bacteriophage lambda · the same entry in another collection · chain O against O, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03040
- Elsewhere: RCSB PDB 5CRO · PDBe 5CRO · UniProt P03040
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