MolNFT v1 · #115706 · protein + DNA
Crystal structure of the MTERF1 F322A substitution bound to the termination sequence.
5CRJ · Transcription termination factor 1, mitochondrial: “Crystal structure of the MTERF1 F322A substitution bound to the termination sequence.”. X-ray diffraction, 3 pockets (best druggability 0.78). MolNFT v1 #115706 on GenesisL1: 3D…
- PDB
- 5CRJ
- Type
- protein + DNA
- Length
- 368 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription termination factor 1, mitochondrial; DNA (5'…
- UniProt
- B4DPR9
- Pockets
- 3 · best druggability 0.78
Structure
x-ray diffraction · 3 distinct chains · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| O | Transcription termination factor 1, mitochondrial | protein | 324 | 72% helix, 0% strand | B4DPR9 |
| D | DNA (5'- D(*AP*TP*TP*AP*CP*CP*GP*GP*GP*CP*TP*CP*TP*GP*CP*CP*AP*TP*CP*TP*TP*A)- 3') | dna | 22 | — | — |
| E | DNA (5'- D(*TP*AP*AP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*CP*CP*CP*GP*GP*TP*AP*AP*T)- 3') | dna | 22 | — | — |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 750 | 0.78 | 0.83 | 66 | empty |
| 2 | 174 | 0.55 | 0.80 | 22 | empty |
| 3 | 66 | 0.31 | 0.75 | 14 | empty |
Interfaces
3 interfaces between chains.
- O–E · 1433 Ų buried · 36 hydrogen bonds · protein-nucleic
- O–D · 1034 Ų buried · 23 hydrogen bonds · protein-nucleic
- D–E · 911 Ų buried · 92 hydrogen bonds · nucleic-nucleic
Compared structures
- 5CRJ · Crystal Structure of the MTERF1 F322A substitution bound to the termination sequence. · the same entry in another collection · chain D against D, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B4DPR9
- Elsewhere: RCSB PDB 5CRJ · PDBe 5CRJ · UniProt B4DPR9
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