MolNFT v1 · #1157 · protein + RNA
Class II aminoacyl transfer RNA synthetases: crystal structure of yeast aspartyl-tRNA synthetase complexed with tRNA asp
1ASY · T-RNA (75-mer): “Class II aminoacyl transfer RNA synthetases: crystal structure of yeast aspartyl-tRNA synthetase complexed…”. X-ray diffraction, 17 pockets (best druggability 0.85). MolNFT v1 #1157 on GenesisL1: 3D structure…
- PDB
- 1ASY
- Type
- protein + RNA
- Length
- 1,130 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- T-RNA (75-mer); Aspartyl-tRNA synthetase
- EC
- 6.1.1.12
- UniProt
- P04802
- Pockets
- 17 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| R, S | T-RNA (75-mer) (EC 6.1.1.12) | rna | 75 | — | — |
| A, B | Aspartyl-tRNA synthetase | protein | 490 | 30% helix, 23% strand | P04802 |
Pockets
17 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 791 | 0.85 | 0.88 | 80 | empty |
| 2 | 515 | 0.82 | 0.88 | 83 | empty |
| 3 | 1079 | 0.80 | 0.82 | 74 | empty |
| 4 | 1149 | 0.79 | 0.81 | 70 | empty |
| 5 | 860 | 0.75 | 0.80 | 48 | empty |
Interfaces
4 interfaces between chains.
- A–B · 4751 Ų buried · 80 hydrogen bonds · protein-protein
- R–A · 2284 Ų buried · 57 hydrogen bonds · protein-nucleic
- S–B · 2161 Ų buried · 63 hydrogen bonds · protein-nucleic
- S–A · 24 Ų buried · 0 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 16 modified (nucleotide modification).
Compared structures
- 1ASY · Class II aminoacyl transfer RNA synthetases: crystal structure of yeast aspartyl-tRNA… · the same entry in another collection · chain R against R, TM-score 1.00
- P04802 · AlphaFold monomer V2.0 prediction for aspartate--tRNA ligase, cytoplasmic (P04802) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04802
- Elsewhere: RCSB PDB 1ASY · PDBe 1ASY · UniProt P04802
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