MolNFT v1 · #115679 · protein
Dimerization of ELP1 is essential for elongator complex assembly
5CQS · Elongator complex protein 1: “Dimerization of ELP1 is essential for elongator complex assembly”. X-ray diffraction, 15 pockets (best druggability 0.79). MolNFT v1 #115679 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5CQS
- Type
- protein
- Length
- 1,285 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Elongator complex protein 1
- UniProt
- Q06706
- Pockets
- 15 · best druggability 0.79
Structure
x-ray diffraction · 4 distinct chains · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Elongator complex protein 1 | protein | 325 | 77% helix, 0% strand | Q06706 |
| B | Elongator complex protein 1 | protein | 323 | 79% helix, 0% strand | Q06706 |
| C | Elongator complex protein 1 | protein | 313 | 73% helix, 0% strand | Q06706 |
| D | Elongator complex protein 1 | protein | 324 | 74% helix, 0% strand | Q06706 |
Pockets
15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 416 | 0.79 | 0.87 | 41 | empty |
| 2 | 234 | 0.70 | 0.86 | 24 | empty |
| 3 | 75 | 0.58 | 0.88 | 24 | empty |
| 4 | 214 | 0.57 | 0.80 | 33 | empty |
| 5 | 196 | 0.55 | 0.79 | 34 | empty |
Interfaces
5 interfaces between chains.
- A–D · 2462 Ų buried · 35 hydrogen bonds · protein-protein
- B–C · 2185 Ų buried · 36 hydrogen bonds · protein-protein
- B–D · 314 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 128 Ų buried · 0 hydrogen bonds · protein-protein
- C–D · 72 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 24 modified (engineered).
Compared structures
- 5CQS · Dimerization of Elp1 is essential for Elongator complex assembly · the same entry in another collection · chain D against D, TM-score 1.00
- Q06706 · AlphaFold monomer V2.0 prediction for elongator complex protein 1 (Q06706) · a predicted model of the same protein · chain B against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06706
- Elsewhere: RCSB PDB 5CQS · PDBe 5CQS · UniProt Q06706
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