MolNFT v1 · #115587 · protein
E. COLI mazf form III
5CO7 · Endoribonuclease mazf: “E. COLI mazf form III”. X-ray diffraction, 11 pockets (best druggability 0.71). MolNFT v1 #115587 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5CO7
- Type
- protein
- Length
- 630 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Endoribonuclease mazf
- EC
- 3.1.27.-
- UniProt
- P0AE70
- Pockets
- 11 · best druggability 0.71
Structure
x-ray diffraction · 6 distinct chains · 23% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Endoribonuclease mazf (EC 3.1.27.-) | protein | 104 | 21% helix, 34% strand | P0AE70 |
| B | Endoribonuclease mazf (EC 3.1.27.-) | protein | 107 | 26% helix, 36% strand | P0AE70 |
| C | Endoribonuclease mazf (EC 3.1.27.-) | protein | 103 | 23% helix, 30% strand | P0AE70 |
| D | Endoribonuclease mazf (EC 3.1.27.-) | protein | 103 | 24% helix, 36% strand | P0AE70 |
| E | Endoribonuclease mazf (EC 3.1.27.-) | protein | 110 | 22% helix, 32% strand | P0AE70 |
| F | Endoribonuclease mazf (EC 3.1.27.-) | protein | 103 | 23% helix, 32% strand | P0AE70 |
Pockets
11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 52 | 0.71 | 0.98 | 20 | empty |
| 2 | 269 | 0.63 | 0.81 | 34 | empty |
| 3 | 173 | 0.62 | 0.84 | 25 | empty |
| 4 | 84 | 0.58 | 0.87 | 19 | empty |
| 5 | 192 | 0.54 | 0.79 | 21 | empty |
Interfaces
4 interfaces between chains.
- A–B · 923 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 861 Ų buried · 7 hydrogen bonds · protein-protein
- E–F · 853 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 585 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- P0AE70 · AlphaFold monomer V2.0 prediction for endoribonuclease toxin mazf (P0AE70) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AE70
- Elsewhere: RCSB PDB 5CO7 · PDBe 5CO7 · UniProt P0AE70
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