MolNFT v1 · #115511 · protein

X-ray structure of perdeuterated ttr mutant - T119M at 1.22A

5CM1 · Transthyretin: “X-ray structure of perdeuterated ttr mutant - T119M at 1.22A”. X-ray diffraction, 2 pockets (best druggability 0.33). MolNFT v1 #115511 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5CM1
Type: protein
Length: 232 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transthyretin
UniProt: P02766
Pockets: 2 · best druggability 0.33

Structure

x-ray diffraction · 1 distinct chain · 6% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Transthyretin	protein	116	6% helix, 53% strand	P02766

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	67	0.33	0.76	16	empty
2	57	0.32	0.77	13	empty

Interfaces

1 interface between chains.

A–B · 940 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

5CM1 · X-ray structure of perdeuterated TTR mutant - T119M at 1.22A · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02766
Elsewhere: RCSB PDB 5CM1 · PDBe 5CM1 · UniProt P02766

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