MolNFT v1 · #115509 · protein
X-ray structure of ttr mutant - T119M at 1.22A resolution
5CLZ · Transthyretin: “X-ray structure of ttr mutant - T119M at 1.22A resolution”. X-ray diffraction, 2 pockets (best druggability 0.32). MolNFT v1 #115509 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5CLZ
- Type
- protein
- Length
- 232 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transthyretin
- UniProt
- P02766
- Pockets
- 2 · best druggability 0.32
Structure
x-ray diffraction · 1 distinct chain · 6% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Transthyretin | protein | 116 | 6% helix, 51% strand | P02766 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 64 | 0.32 | 0.76 | 16 | empty |
| 2 | 60 | 0.31 | 0.76 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 936 Ų buried · 18 hydrogen bonds · protein-protein
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02766
- Elsewhere: RCSB PDB 5CLZ · PDBe 5CLZ · UniProt P02766
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