MolNFT v1 · #11545 · protein
Mutation that destabilize the GP41 core: determinants for stabilizing the SIV/CPMAC envelope glycoprotein complex. wild type.
1JPX · GP41 envelope protein: “Mutation that destabilize the GP41 core: determinants for stabilizing the SIV/CPMAC envelope glycoprotein…”. X-ray diffraction, 1 pocket (best druggability 0.54). MolNFT v1 #11545 on GenesisL1: 3D structure…
- PDB
- 1JPX
- Type
- protein
- Length
- 172 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GP41 envelope protein
- UniProt
- Q87972
- Pockets
- 1 · best druggability 0.54
Structure
x-ray diffraction · 3 distinct chains · 90% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GP41 envelope protein | protein | 59 | 88% helix, 0% strand | Q87972 |
| D | GP41 envelope protein | protein | 57 | 91% helix, 0% strand | Q87972 |
| G | GP41 envelope protein | protein | 56 | 91% helix, 0% strand | Q87972 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 293 | 0.54 | 0.75 | 32 | empty |
Interfaces
1 interface between chains.
- D–G · 337 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 1JPX · Mutation that destabilize the gp41 core: determinants for stabilizing the SIV/CPmac… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q87972
- Elsewhere: RCSB PDB 1JPX · PDBe 1JPX · UniProt Q87972
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