MolNFT v1 · #115371 · protein

Fab fragments of chikungunya virus neutralizing human monoclonal antibody 5M16

5CHN · Antibody 5M16 Fab heavy chain: “Fab fragments of chikungunya virus neutralizing human monoclonal antibody 5M16”. X-ray diffraction, 3 pockets (best druggability 0.75). MolNFT v1 #115371 on GenesisL1: 3D structure, binding sites and…

PDB: 5CHN
Type: protein
Length: 865 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Antibody 5M16 Fab heavy chain; Antibody 5M16 Fab light chain
Pockets: 3 · best druggability 0.75

Structure

x-ray diffraction · 3 distinct chains · 8% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Antibody 5M16 Fab heavy chain	protein	215	11% helix, 52% strand	—
L, B	Antibody 5M16 Fab light chain	protein	218	5% helix, 50% strand	—
A	Antibody 5M16 Fab heavy chain	protein	214	9% helix, 51% strand	—

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	991	0.75	0.78	97	empty
2	250	0.54	0.77	35	empty
3	331	0.54	0.74	43	empty

Interfaces

4 interfaces between chains.

H–L · 1675 Å² buried · 17 hydrogen bonds · protein-protein
A–B · 1665 Å² buried · 16 hydrogen bonds · protein-protein
H–B · 327 Å² buried · 5 hydrogen bonds · protein-protein
L–B · 121 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 7 disulfide (disulfide).

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5CHN · PDBe 5CHN

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.