MolNFT v1 · #11530 · protein
PHE232LEU mutant of human urod, human uroporphyrinogen III decarboxylase
1JPI · Uroporphyrinogen decarboxylase: “PHE232LEU mutant of human urod, human uroporphyrinogen III decarboxylase”. X-ray diffraction, 1 pocket (best druggability 0.71). MolNFT v1 #11530 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 1JPI
- Type
- protein
- Length
- 357 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uroporphyrinogen decarboxylase
- EC
- 4.1.1.37
- UniProt
- P06132
- Pockets
- 1 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uroporphyrinogen decarboxylase (EC 4.1.1.37) | protein | 357 | 52% helix, 10% strand | P06132 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 469 | 0.71 | 0.81 | 43 | empty |
Compared structures
- 1JPI · Phe232Leu mutant of human UROD, human uroporphyrinogen III decarboxylase · the same entry in another collection · chain A against A, TM-score 1.00
- P06132 · AlphaFold monomer V2.0 prediction for uroporphyrinogen decarboxylase (P06132) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06132
- Elsewhere: RCSB PDB 1JPI · PDBe 1JPI · UniProt P06132
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