MolNFT v1 · #115183 · protein

Structure of the ligand-binding domain of the ionotropic glutamate receptor-like GLUD2 in complex with 7-cka

5CC2 · Glutamate receptor ionotropic, delta-2: “Structure of the ligand-binding domain of the ionotropic glutamate receptor-like GLUD2 in complex with 7-cka”. X-ray diffraction, 2 ligands (CKA, CL), 2 pockets (best druggability 0.71).…

PDB: 5CC2
Type: protein
Length: 256 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutamate receptor ionotropic, delta-2
UniProt: Q63226
Ligands: CKA, CL
Pockets: 2 · best druggability 0.71

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glutamate receptor ionotropic, delta-2	protein	256	37% helix, 31% strand	Q63226

Ligands and binding sites

CKA · 7-chlorokynurenic acid · ligand · 3 copies · chains A
CL · Chloride ion · ion · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	547	0.71	0.80	59	CKA, GOL
2	66	0.27	0.72	15	empty

Compared structures

Q63226 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, delta-2 (Q63226) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q63226
Elsewhere: RCSB PDB 5CC2 · PDBe 5CC2 · UniProt Q63226

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