MolNFT v1 · #115063 · protein

Crystal structure of light-exposed full-length thermus thermophilus carh bound to cobalamin

5C8F · Light-dependent transcriptional regulator carh: “Crystal structure of light-exposed full-length thermus thermophilus carh bound to cobalamin”. X-ray diffraction, 2 ligands (B12, CL), 3 pockets (best druggability 0.58). MolNFT v1…

PDB: 5C8F
Type: protein
Length: 274 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Light-dependent transcriptional regulator carh
UniProt: Q746J7
Ligands: B12, CL
Pockets: 3 · best druggability 0.58

Structure

x-ray diffraction · 1 distinct chain · 58% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Light-dependent transcriptional regulator carh	protein	274	58% helix, 11% strand	Q746J7

Ligands and binding sites

B12 · Cobalamin · ligand · chains A
CL · Chloride ion · ion · 2 copies · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	281	0.58	0.78	37	B12
2	75	0.31	0.74	21	empty
3	71	0.30	0.73	13	empty

Compared structures

5C8F · Crystal structure of light-exposed full-length Thermus thermophilus CarH bound to… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q746J7
Elsewhere: RCSB PDB 5C8F · PDBe 5C8F · UniProt Q746J7

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