MolNFT v1 · #115033 · protein
Structure of human testis-specific glyceraldehyde-3-phosphate dehydrogenase apo form
5C7L · Glyceraldehyde-3-phosphate dehydrogenase, testis-specific: “Structure of human testis-specific glyceraldehyde-3-phosphate dehydrogenase apo form”. X-ray diffraction, 3 pockets (best druggability 0.63). MolNFT v1 #115033 on…
- PDB
- 5C7L
- Type
- protein
- Length
- 672 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
- EC
- 1.2.1.12
- UniProt
- O14556
- Pockets
- 3 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 33% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| O, R | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (EC 1.2.1.12) | protein | 336 | 33% helix, 26% strand | O14556 |
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 570 | 0.63 | 0.75 | 59 | empty |
| 2 | 501 | 0.62 | 0.75 | 63 | empty |
| 3 | 355 | 0.58 | 0.76 | 37 | empty |
Interfaces
1 interface between chains.
- O–R · 635 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (oxidation).
Compared structures
- 5C7L · Structure of human testis-specific glyceraldehyde-3-phosphate dehydrogenase apo form · the same entry in another collection · chain O against O, TM-score 1.00
- O14556 · AlphaFold monomer V2.0 prediction for glyceraldehyde-3-phosphate dehydrogenase… · a predicted model of the same protein · chain R against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14556
- Elsewhere: RCSB PDB 5C7L · PDBe 5C7L · UniProt O14556
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