MolNFT v1 · #115030 · protein

Mouse sperm glyceraldehyde-3-phosphate dehydrogenase: apo enzyme

5C7I · Glyceraldehyde-3-phosphate dehydrogenase, testis-specific: “Mouse sperm glyceraldehyde-3-phosphate dehydrogenase: apo enzyme”. X-ray diffraction, 3 pockets (best druggability 0.62). MolNFT v1 #115030 on GenesisL1: 3D structure…

PDB: 5C7I
Type: protein
Length: 666 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
EC: 1.2.1.12
UniProt: Q64467
Pockets: 3 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
O, R	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (EC 1.2.1.12)	protein	333	30% helix, 27% strand	Q64467

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	379	0.62	0.78	38	empty
2	355	0.61	0.78	36	empty
3	358	0.60	0.77	44	empty

Interfaces

1 interface between chains.

O–R · 628 Å² buried · 13 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (oxidation).

Compared structures

5C7I · Mouse sperm Glyceraldehyde-3-phosphate dehydrogenase: apo enzyme · the same entry in another collection · chain O against O, TM-score 1.00
Q64467 · AlphaFold monomer V2.0 prediction for glyceraldehyde-3-phosphate dehydrogenase… · a predicted model of the same protein · chain O against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q64467
Elsewhere: RCSB PDB 5C7I · PDBe 5C7I · UniProt Q64467

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