MolNFT v1 · #115018 · protein
ATP-driven lipid-linked oligosaccharide flippase pglk in apo-inward facing state (2)
5C76 · Wlab protein: “ATP-driven lipid-linked oligosaccharide flippase pglk in apo-inward facing state (2)”. X-ray diffraction, 20 pockets (best druggability 0.84). MolNFT v1 #115018 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5C76
- Type
- protein
- Length
- 2,256 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Wlab protein
- UniProt
- O86150
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 58% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Wlab protein | protein | 564 | 58% helix, 4% strand | O86150 |
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1149 | 0.84 | 0.84 | 96 | empty |
| 2 | 1134 | 0.83 | 0.83 | 106 | empty |
| 3 | 260 | 0.62 | 0.81 | 30 | empty |
| 4 | 259 | 0.61 | 0.80 | 33 | empty |
| 5 | 216 | 0.60 | 0.81 | 33 | empty |
Interfaces
5 interfaces between chains.
- B–C · 6343 Ų buried · 36 hydrogen bonds · protein-protein
- A–D · 6234 Ų buried · 34 hydrogen bonds · protein-protein
- A–B · 510 Ų buried · 11 hydrogen bonds · protein-protein
- A–C · 399 Ų buried · 3 hydrogen bonds · protein-protein
- B–D · 308 Ų buried · 3 hydrogen bonds · protein-protein
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O86150
- Elsewhere: RCSB PDB 5C76 · PDBe 5C76 · UniProt O86150
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