MolNFT v1 · #114941 · protein

Cobk precorrin-6A reductase

5C4R: “Cobk precorrin-6A reductase”. X-ray diffraction, 2 pockets (best druggability 0.61). MolNFT v1 #114941 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5C4R
Type: protein
Length: 245 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Precorrin-6A reductase
EC: 1.3.1.54
UniProt: O68098
Pockets: 2 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 29% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Precorrin-6A reductase (EC 1.3.1.54)	protein	245	29% helix, 21% strand	O68098

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	294	0.61	0.79	39	empty
2	50	0.32	0.78	14	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

5C4R · CobK precorrin-6A reductase · the same entry in another collection · chain A against A, TM-score 1.00
O68098 · AlphaFold monomer V2.0 prediction for precorrin-6A reductase (O68098) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O68098
Elsewhere: RCSB PDB 5C4R · PDBe 5C4R · UniProt O68098

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