MolNFT v1 · #114712 · protein
H18 bat influenza NS1 RNA binding domain
5BY1 · Non-structural protein 1: “H18 bat influenza NS1 RNA binding domain”. X-ray diffraction, 2 pockets (best druggability 0.58). MolNFT v1 #114712 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5BY1
- Type
- protein
- Length
- 142 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Non-structural protein 1
- UniProt
- U5N1D7
- Pockets
- 2 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 85% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Non-structural protein 1 | protein | 71 | 83% helix, 0% strand | U5N1D7 |
| B | Non-structural protein 1 | protein | 71 | 86% helix, 0% strand | U5N1D7 |
Ligands and binding sites
- PEG · Di(hydroxyethyl)ether · additive · chains A
- 1PE · Pentaethylene glycol · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 169 | 0.58 | 0.82 | 21 | empty |
| 2 | 66 | 0.52 | 0.86 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1154 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 5BY1 · H18 Bat Influenza NS1 RNA Binding Domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt U5N1D7
- Elsewhere: RCSB PDB 5BY1 · PDBe 5BY1 · UniProt U5N1D7
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