MolNFT v1 · #114691 · protein
Crystal structure of pentameric KCTD1 btb domain form 2
5BXD · BTB/POZ domain-containing protein KCTD1: “Crystal structure of pentameric KCTD1 btb domain form 2”. X-ray diffraction, 8 pockets (best druggability 0.47). MolNFT v1 #114691 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5BXD
- Type
- protein
- Length
- 522 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- BTB/POZ domain-containing protein KCTD1
- UniProt
- Q719H9
- Pockets
- 8 · best druggability 0.47
Structure
x-ray diffraction · 4 distinct chains · 42% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | BTB/POZ domain-containing protein KCTD1 | protein | 101 | 41% helix, 11% strand | Q719H9 |
| B, C | BTB/POZ domain-containing protein KCTD1 | protein | 104 | 41% helix, 14% strand | Q719H9 |
| D | BTB/POZ domain-containing protein KCTD1 | protein | 107 | 44% helix, 12% strand | Q719H9 |
| E | BTB/POZ domain-containing protein KCTD1 | protein | 106 | 42% helix, 18% strand | Q719H9 |
Pockets
8 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 128 | 0.47 | 0.78 | 17 | empty |
| 2 | 127 | 0.45 | 0.77 | 19 | empty |
| 3 | 118 | 0.44 | 0.77 | 17 | empty |
| 4 | 108 | 0.39 | 0.75 | 18 | empty |
| 5 | 78 | 0.34 | 0.75 | 21 | empty |
Interfaces
4 interfaces between chains.
- D–E · 871 Ų buried · 18 hydrogen bonds · protein-protein
- B–C · 870 Ų buried · 23 hydrogen bonds · protein-protein
- A–B · 867 Ų buried · 21 hydrogen bonds · protein-protein
- C–D · 817 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 5BXD · Crystal structure of pentameric KCTD1 BTB domain form 2 · the same entry in another collection · chain E against E, TM-score 1.00
- Q719H9 · AlphaFold monomer V2.0 prediction for BTB/POZ domain-containing protein KCTD1 (Q719H9) · a predicted model of the same protein · chain E against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q719H9
- Elsewhere: RCSB PDB 5BXD · PDBe 5BXD · UniProt Q719H9
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.