MolNFT v1 · #114634 · protein

X-ray structure of interferon regulatory factor 4 iad domain

5BVI: “X-ray structure of interferon regulatory factor 4 iad domain”. X-ray diffraction, 1 ligand (CL), 4 pockets (best druggability 0.50). MolNFT v1 #114634 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5BVI
Type: protein
Length: 363 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Interferon regulatory factor 4
UniProt: Q5SUZ4
Ligands: CL
Pockets: 4 · best druggability 0.50

Structure

x-ray diffraction · 2 distinct chains · 22% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Interferon regulatory factor 4	protein	182	23% helix, 31% strand	Q5SUZ4
B	Interferon regulatory factor 4	protein	181	21% helix, 32% strand	Q5SUZ4

Ligands and binding sites

CL · Chloride ion · ion · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	308	0.50	0.73	30	empty
2	112	0.41	0.76	18	empty
3	73	0.33	0.75	20	empty
4	52	0.26	0.74	12	empty

Interfaces

1 interface between chains.

A–B · 716 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

5BVI · X-ray Structure of Interferon Regulatory Factor 4 IAD Domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5SUZ4
Elsewhere: RCSB PDB 5BVI · PDBe 5BVI · UniProt Q5SUZ4

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