MolNFT v1 · #114616 · protein
Crystal structure of a complex between the snare VAM3 and the hops VPS33-VPS16 subcomplex from chaetomium thermophilum
5BUZ · Sm (SEC1/MUNC18-like) protein: “Crystal structure of a complex between the snare VAM3 and the hops VPS33-VPS16 subcomplex from chaetomium…”. X-ray diffraction, 20 pockets (best druggability 0.79). MolNFT v1 #114616 on GenesisL1: 3D…
- PDB
- 5BUZ
- Type
- protein
- Length
- 1,936 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sm (SEC1/MUNC18-like) protein; Putative vacuolar protein sorting-associated protein; Snap…
- UniProt
- G0SCM5, G0S6M7, G0S236
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 4 distinct chains · 57% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Sm (SEC1/MUNC18-like) protein | protein | 605 | 49% helix, 15% strand | G0SCM5 |
| B, E | Putative vacuolar protein sorting-associated protein | protein | 324 | 69% helix, 0% strand | G0S6M7 |
| C | Snap receptor-like protein | protein | 38 | 63% helix, 0% strand | G0S236 |
| F | Snap receptor-like protein | protein | 40 | 70% helix, 0% strand | G0S236 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1144 | 0.79 | 0.81 | 127 | empty |
| 2 | 654 | 0.78 | 0.83 | 67 | empty |
| 3 | 746 | 0.73 | 0.78 | 75 | empty |
| 4 | 51 | 0.72 | 0.99 | 18 | empty |
| 5 | 559 | 0.70 | 0.79 | 61 | empty |
Interfaces
6 interfaces between chains.
- D–E · 2482 Ų buried · 30 hydrogen bonds · protein-protein
- A–B · 2469 Ų buried · 25 hydrogen bonds · protein-protein
- D–F · 897 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 863 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 309 Ų buried · 4 hydrogen bonds · protein-protein
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0SCM5
- Every structure of UniProt G0S6M7
- Every structure of UniProt G0S236
- Elsewhere: RCSB PDB 5BUZ · PDBe 5BUZ · UniProt G0SCM5 · UniProt G0S6M7 · UniProt G0S236
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.