MolNFT v1 · #114452 · protein
Crystal structure of zaire ebolavirus VP35 RNA binding domain mutant I278A
5BPV · Polymerase cofactor VP35: “Crystal structure of zaire ebolavirus VP35 RNA binding domain mutant I278A”. X-ray diffraction, 1 pocket (best druggability 0.72). MolNFT v1 #114452 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5BPV
- Type
- protein
- Length
- 247 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polymerase cofactor VP35
- UniProt
- Q6V1Q9
- Pockets
- 1 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 53% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Polymerase cofactor VP35 | protein | 124 | 52% helix, 13% strand | Q6V1Q9 |
| B | Polymerase cofactor VP35 | protein | 123 | 53% helix, 13% strand | Q6V1Q9 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 863 | 0.72 | 0.77 | 56 | empty |
Interfaces
1 interface between chains.
- A–B · 273 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 5BPV · Crystal Structure of Zaire ebolavirus VP35 RNA binding domain mutant I278A · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6V1Q9
- Elsewhere: RCSB PDB 5BPV · PDBe 5BPV · UniProt Q6V1Q9
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