MolNFT v1 · #114388 · protein
Crystal structure of glutamine-tRNA ligase /glutaminyl-tRNA synthetase (glnrs) from pseudomonas aeruginosa
5BNZ · Glutamine--tRNA ligase: “Crystal structure of glutamine-tRNA ligase /glutaminyl-tRNA synthetase (glnrs) from pseudomonas aeruginosa”. X-ray diffraction, 2 ligands (SO4, CL), 15 pockets (best druggability 0.75). MolNFT v1 #114388 on…
- PDB
- 5BNZ
- Type
- protein
- Length
- 1,096 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamine--tRNA ligase
- EC
- 6.1.1.18
- UniProt
- Q9I2U8
- Ligands
- SO4, CL
- Pockets
- 15 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 30% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Glutamine--tRNA ligase (EC 6.1.1.18) | protein | 548 | 30% helix, 25% strand | Q9I2U8 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 101 | 0.75 | 0.96 | 29 | empty |
| 2 | 102 | 0.75 | 0.96 | 30 | empty |
| 3 | 390 | 0.64 | 0.78 | 33 | empty |
| 4 | 361 | 0.64 | 0.79 | 33 | empty |
| 5 | 80 | 0.50 | 0.83 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 277 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- Q9I2U8 · AlphaFold monomer V2.0 prediction for glutamine--tRNA ligase (Q9I2U8) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9I2U8
- Elsewhere: RCSB PDB 5BNZ · PDBe 5BNZ · UniProt Q9I2U8
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