MolNFT v1 · #114370 · protein + DNA
Monomer of tale type homeobox transcription factor MEIS1 complexes with specific DNA
5BNG · Homeobox protein MEIS2: “Monomer of tale type homeobox transcription factor MEIS1 complexes with specific DNA”. X-ray diffraction, 4 pockets (best druggability 0.45). MolNFT v1 #114370 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5BNG
- Type
- protein + DNA
- Length
- 163 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Homeobox protein MEIS2; DNA (5'-D(P*TP*TP*AP*GP*CP*TP*GP*TP*CP*A)-3'); DNA…
- UniProt
- O14770
- Pockets
- 4 · best druggability 0.45
Structure
x-ray diffraction · 6 distinct chains · 70% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Homeobox protein MEIS2 | protein | 60 | 75% helix, 0% strand | O14770 |
| L | DNA (5'-D(P*TP*TP*AP*GP*CP*TP*GP*TP*CP*A)-3') | dna | 10 | — | — |
| M | DNA (5'-D(P*TP*GP*AP*CP*AP*GP*CP*TP*AP*A-3') | dna | 12 | — | — |
| A | Homeobox protein MEIS2 | protein | 59 | 64% helix, 0% strand | O14770 |
| C | DNA (5'-D(P*AP*AP*TP*TP*AP*GP*CP*TP*GP*TP*CP*A)-3') | dna | 12 | — | — |
| D | DNA (5'-D(P*TP*GP*AP*CP*AP*GP*CP*TP*AP*A)-3') | dna | 10 | — | — |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 164 | 0.45 | 0.76 | 15 | empty |
| 2 | 107 | 0.42 | 0.77 | 16 | empty |
| 3 | 114 | 0.41 | 0.76 | 18 | empty |
| 4 | 152 | 0.38 | 0.73 | 19 | empty |
Interfaces
9 interfaces between chains.
- L–M · 457 Ų buried · 29 hydrogen bonds · nucleic-nucleic
- C–D · 418 Ų buried · 34 hydrogen bonds · nucleic-nucleic
- B–M · 350 Ų buried · 4 hydrogen bonds · protein-nucleic
- A–C · 344 Ų buried · 8 hydrogen bonds · protein-nucleic
- A–D · 329 Ų buried · 7 hydrogen bonds · protein-nucleic
Compared structures
- 5BNG · monomer of TALE type homeobox transcription factor MEIS1 complexes with specific DNA · the same entry in another collection · chain M against M, TM-score 1.00
- O14770 · AlphaFold monomer V2.0 prediction for homeobox protein MEIS2 (O14770) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14770
- Elsewhere: RCSB PDB 5BNG · PDBe 5BNG · UniProt O14770
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