MolNFT v1 · #114207 · protein
The crystal structure of a crustacean hyperglycemic hormone precursor from the kuruma prawn
5B5I · Crustacean hyperglycemic hormones 1: “The crystal structure of a crustacean hyperglycemic hormone precursor from the kuruma prawn”. X-ray diffraction, 2 pockets (best druggability 0.70). MolNFT v1 #114207 on GenesisL1: 3D structure…
- PDB
- 5B5I
- Type
- protein
- Length
- 135 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Crustacean hyperglycemic hormones 1
- UniProt
- O15980
- Pockets
- 2 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 59% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Crustacean hyperglycemic hormones 1 | protein | 67 | 60% helix, 0% strand | O15980 |
| B | Crustacean hyperglycemic hormones 1 | protein | 68 | 59% helix, 0% strand | O15980 |
Ligands and binding sites
- EOH · Ethanol · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 327 | 0.70 | 0.83 | 30 | empty |
| 2 | 96 | 0.60 | 0.87 | 25 | EOH |
Interfaces
1 interface between chains.
- A–B · 1047 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 5B5I · The crystal structure of a crustacean hyperglycemic hormone precursor from the kuruma… · the same entry in another collection · chain A against A, TM-score 1.00
- O15980 · AlphaFold monomer V2.0 prediction for crustacean hyperglycemic hormones 1 (O15980) · a predicted model of the same protein · chain A against A, TM-score 0.68
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15980
- Elsewhere: RCSB PDB 5B5I · PDBe 5B5I · UniProt O15980
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